Biomarker Discovery
Biomarker Discovery
Biomarkers, such as proteins, are naturally occurring biomolecules useful for measuring the prognosis and/or progress of diseases and therapies. They are normally present in small amounts in blood or tissue. When the amounts of these molecules change, they may indicate disease. Poochon developed a reliable platform, PROMICMAPPER, and a novel proteomic pathway analysis tool, PROMICPATH, for quantitative global protein profiling and proteomic pathway analysis, which is an ideal combination to differentiate diseased and normal samples for biomarker discovery.
Identification of Differentially Expressed Proteins From Two Groups of Samples
Turnaround Time: 10 to 15 business days
Service Description
• Identification of differentially expressed proteins from two groups of samples (e.g., healthy and diseased)
• Workflow: Sample preparation, LC-MS/MS analysis, data analysis, and results report
Deliverables
• Protein Biomarker Profiling Report
• List of identified proteins with relative abundance
• List of all identified proteins with matched peptides sequences
• List of protein biomarker candidates that are differentially expressed among samples (e.g., > 2 folds)
• Data normalization, statistical analysis, volcano plots, heat maps
• Data figures
Suitable Sample Type
• Frozen cell pellets, tissues, or serum/plasma samples
• Identification of differentially expressed proteins from two groups of samples (e.g., healthy and diseased)
• Workflow: Sample preparation, LC-MS/MS analysis, data analysis, and results report
• Protein Biomarker Profiling Report
• List of identified proteins with relative abundance
• List of all identified proteins with matched peptides sequences
• List of protein biomarker candidates that are differentially expressed among samples (e.g., > 2 folds)
• Data normalization, statistical analysis, volcano plots, heat maps
• Data figures
• Frozen cell pellets, tissues, or serum/plasma samples